Molecular site of substituents of benz(a)anthracene related to carcinogenicity.
نویسندگان
چکیده
The tumor-producing effect of dibenz(a,h)anthracene led Cook (5) to undertake experiments showing that 9-isopropyl BA is a (weak) carcinogenand Fieseret aL (9) synthesized the stronger cancer-producing substances 7-methyl-BA and 7,8-DMBA. Considerably later it was found that 7,12-DMBA (1), 7,8,12-TMBA (1), and 6,7,8-TMBA (21) are very powerful carcinogens. It was evident that substitution of BA at positions 7 and 8 to form cholanthrene or 7,8-DMBA was more effective in promoting carcinogenic potency than substitution of BA at positions 8 and 9 was, irrespective of whether a new ring was formed or the substituents remained as alkyl groups.
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عنوان ژورنال:
- Cancer research
دوره 29 3 شماره
صفحات -
تاریخ انتشار 1969